Characterizing Cellular Physiological States with Three-Dimensional Shape Descriptors for Cell Membranes.

ABSTRACT: The shape of a cell as defined by its membrane can be closely associated with its physiological state. For example, the irregular shapes of cancerous cells and elongated shapes of neuron cells often reflect specific functions, such as cell motility and cell communication. However, it remains unclear whether and which cell shape descriptors can characterize different cellular physiological states. In this study, 12 geometric shape descriptors for a three-dimensional (3D) object were collected from the previous literature and tested with a public dataset of ~400,000 independent 3D cell regions segmented based on fluorescent labeling of the cell membranes in Caenorhabditis elegans embryos. It is revealed that those shape descriptors can faithfully characterize cellular physiological st

SUBMITTER: Guan G 

PROVIDER: S-EPMC11205511 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature