Druggability Analysis of Protein Targets for Drug Discovery to Combat Listeria monocytogenes.

ABSTRACT: Extensive research has been conducted to identify key proteins governing stress responses, virulence, and antimicrobial resistance, as well as to elucidate their interactions within Listeria monocytogenes. While these proteins hold promise as potential targets for novel strategies to control L. monocytogenes, given their critical roles in regulating the pathogen's metabolism, additional analysis is needed to further assess their druggability-the chance of being effectively bound by small-molecule inhibitors. In this work, 535 binding pockets of 46 protein targets for known drugs (mainly antimicrobials) were first analyzed to extract 13 structural features (e.g., hydrophobicity) in a ligand-protein docking platform called Molsoft ICM Pro. The extracted features were used as in

SUBMITTER: Hanes R 

PROVIDER: S-EPMC11205737 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature