Discovery of Delirium Biomarkers through Minimally Invasive Serum Molecular Fingerprinting.

ABSTRACT: Delirium presents a significant clinical challenge, primarily due to its profound impact on patient outcomes and the limitations of the current diagnostic methods, which are largely subjective. During the COVID-19 pandemic, this challenge was intensified as the frequency of delirium assessments decreased in Intensive Care Units (ICUs), even as the prevalence of delirium among critically ill patients increased. The present study evaluated how the serum molecular fingerprint, as acquired by Fourier-Transform InfraRed (FTIR) spectroscopy, can enable the development of predictive models for delirium. A preliminary univariate analysis of serum FTIR spectra indicated significantly different bands between 26 ICU patients with delirium and 26 patients without, all of whom were admitted with COVID-

SUBMITTER: Viegas A 

PROVIDER: S-EPMC11205956 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature