Patients' Experiences of Clozapine for Treatment-Resistant Schizophrenia: A Systematic Review.

ABSTRACT:

Background

Clozapine is the most effective antipsychotic for patients with treatment-resistant schizophrenia (TRS), however, it remains widely under-utilized in clinical practice. To date, relatively little attention has been given to patients' experience of clozapine. By synthesizing the existing literature, we sought to determine the experiences of patients with TRS treated with clozapine.

Methods

A systematic review was conducted on Embase, Medline, PsychInfo, and PubMed databases for studies from 1956 to 2021. English language studies and those based on adult patients prescribed clozapine for TRS were included.

Results

Thirteen studies were included with a total of 1487 patients and a narrative synthesis was performed. Overall, most patients reported positive expe

SUBMITTER: Parkes S 

PROVIDER: S-EPMC11205966 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature