Identification and Characterization of Cannabichromene's Major Metabolite Following Incubation with Human Liver Microsomes.

ABSTRACT: Cannabichromene (CBC) is a minor cannabinoid within the array of over 120 cannabinoids identified in the Cannabis sativa plant. While CBC does not comprise a significant portion of whole plant material, it is available to the public in a purified and highly concentrated form. As minor cannabinoids become more popular due to their potential therapeutic properties, it becomes crucial to elucidate their metabolism in humans. Therefore, the goal of this was study to identify the major CBC phase I-oxidized metabolite generated in vitro following incubation with human liver microsomes. The novel metabolite structure was identified as 2'-hydroxycannabicitran using gas chromatography-mass spectrometry and nuclear magnetic resonance spectroscopy. Following the identification, in silico molec

SUBMITTER: Ward AM 

PROVIDER: S-EPMC11206029 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature