The Electroretinogram as a Potential Biomarker of Psychosis in Children at Familial Risk.

ABSTRACT: We previously proposed the electroretinogram (ERG) as a promising biomarker of major psychiatric disorders such as schizophrenia (SZ) and bipolar disorder (BP), given that we found anomalies in the ERG parameters of patients with these diagnoses as well as in their children who are at high risk (HR) of developing such disorders. The aim of the present study is to investigate the usefulness of the ERG for individual detection, among HR children, of an ERG profile resembling that of a SZ patient, as this may indicate a stronger likelihood of transition to psychosis. Using a logistic regression model previously derived from the ERG assessments of SZ patients and control (CT) subjects, individual risk scores were obtained for 61 HR and 80 CT youth. Those with a very high individual risk score

SUBMITTER: Moreau I 

PROVIDER: S-EPMC11206048 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature