Dysmaturational Longitudinal Epigenetic Aging During Transition to Psychosis.

ABSTRACT: Psychosis frequently occurs during adolescence and young adulthood, possibly as a result of gene-environment interactions, mediated by epigenetic mechanisms such as DNA methylation. Methylation patterns can be leveraged to predict epigenetic age in order to identify anomalies in aging trajectories that may be associated with the emergence of psychosis. Thus, epigenetic age may provide a measurable surrogate of psychotic risk or psychosis' emergence, and shed light on the neurodevelopmental model of psychosis. In this study, we present the first longitudinal analysis of epigenetic age trajectory during conversion to psychosis in a population at ultra-high-risk, with available genome-wide methylation DNA at two time points, at baseline and after one year of follow-up (N = 38 × 2). Aft

SUBMITTER: Iftimovici A 

PROVIDER: S-EPMC11206049 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature