Magnetic Particle Imaging-Guided Thermal Simulations for Magnetic Particle Hyperthermia.

ABSTRACT: Magnetic particle hyperthermia (MPH) enables the direct heating of solid tumors with alternating magnetic fields (AMFs). One challenge with MPH is the unknown particle distribution in tissue after injection. Magnetic particle imaging (MPI) can measure the nanoparticle content and distribution in tissue after delivery. The objective of this study was to develop a clinically translatable protocol that incorporates MPI data into finite element calculations for simulating tissue temperatures during MPH. To verify the protocol, we conducted MPH experiments in tumor-bearing mouse cadavers. Five 8-10-week-old female BALB/c mice bearing subcutaneous 4T1 tumors were anesthetized and received intratumor injections of Synomag^®-S90 nanoparticles. Immediately following injection, the mice we

SUBMITTER: Carlton H 

PROVIDER: S-EPMC11206764 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature