Comparative Analysis of Immune Gene Transcription in Sea Bream (<i>Sparus aurata</i>) Challenged with RGNNV or RGNNV/SJNNV Betanodaviruses.

ABSTRACT: Gilthead sea bream and European sea bass display different resistance-susceptibility patterns during infection with different nervous necrosis virus (NNV) species, which may derive from differences in the triggered immune response. Based on this premise, we analysed the transcription of several selected immune-related genes in sea bream experimentally infected with NNV isolates obtained from sea bass (DlNNV, RGNNV) or sea bream (SaNNV, RGNNV/SJNNV). Viral replication only occurred in SaNNV-inoculated fish; therefore, the differences between the immune response elicited by both viruses may be the key to understanding the mechanism behind the inhibition of DlNNV replication. Principal component analysis clustered samples according to the viral isolate from 1 day post infection onwards and ev

SUBMITTER: Gemez-Mata J 

PROVIDER: S-EPMC11207047 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature