Perioperative platelet reactivity over time in patients undergoing vascular surgery: An observational pilot study.

ABSTRACT:

Background

Despite Antiplatelet therapy (APT), cardiovascular patients undergoing revascularisation remain at high risk for thrombotic events. Individual response to APT varies substantially, resulting in insufficient protection from thrombotic events due to high on-treatment platelet reactivity (HTPR) in ≤40% of patients. Individual variation in platelet response impairs APT guidance on a single patient level. Unfortunately, little is known about individual platelet response to APT over time, timing for accurate residual platelet reactivity measurement, or the optimal test to monitor residual platelet reactivity.

Aims

To investigate residual platelet reactivity variability over time in individual patients undergoing carotid endarterectomy (CEA) treated with clopidogrel.

SUBMITTER: Brand Kanters ART 

PROVIDER: S-EPMC11207130 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature