Increased lipogenesis and lipidosis of gallbladder epithelium in dogs with gallbladder mucocele formation.

ABSTRACT:

Background

Gallbladder disease in people is frequently associated with disorders of lipid metabolism and metabolic syndrome. A recently emergent gallbladder disease of dogs, referred to as mucocele formation, is characterized by secretion of abnormal mucus by the gallbladder epithelium and is similarly associated with hyperlipidemia, endocrinopathy, and metabolic dysfunction. The cause of gallbladder mucocele formation in dogs is unknown.

Methods

A prospective case-controlled study was conducted to gain insight into disease pathogenesis by characterization of plasma lipid abnormalities in 18 dogs with gallbladder mucocele formation and 18 age and breed matched control dogs using direct infusion mass spectrometry for complex plasma lipid analysis. This analysis was complement

SUBMITTER: Gookin JL 

PROVIDER: S-EPMC11207163 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature