Post-mortem changes of anisotropic mechanical properties in the porcine brain assessed by MR elastography.

ABSTRACT: Knowledge of the mechanical properties of brain tissue in vivo is essential to understanding the mechanisms underlying traumatic brain injury (TBI) and to creating accurate computational models of TBI and neurosurgical simulation. Brain white matter, which is composed of aligned, myelinated, axonal fibers, is structurally anisotropic. White matter in vivo also exhibits mechanical anisotropy, as measured by magnetic resonance elastography (MRE), but measurements of anisotropy obtained by mechanical testing of white matter ex vivo have been inconsistent. The minipig has a gyrencephalic brain with similar white matter and gray matter proportions to humans and therefore provides a relevant model for human brain mechanics. In this study, we compare estimates of anisotropic

SUBMITTER: Wang S 

PROVIDER: S-EPMC11207183 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature