Eye Movement Abnormalities Can Distinguish First-Episode Schizophrenia, Chronic Schizophrenia, and Prodromal Patients From Healthy Controls.

ABSTRACT:

Background

This study attempts to replicate in a Chinese population an earlier UK report that eye movement abnormalities can accurately distinguish schizophrenia (SCZ) cases from healthy controls (HCs). It also seeks to determine whether first-episode SCZ differ from chronic SCZ and whether these eye movement abnormalities are enriched in psychosis risk syndrome (PRS).

Methods

The training set included 104 Chinese HC and 60 Chinese patients with SCZ, and the testing set included 20 SCZ patients and 20 HC from a UK cohort. An additional 16 individuals with PRS were also enrolled. Eye movements of all participants were recorded during free-viewing, smooth pursuit, and fixation stability tasks. Group differences in 55 performance measures were compared and a gradient-boosted de

SUBMITTER: Lyu H 

PROVIDER: S-EPMC11207660 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature