Hippocampal Glutamate, Resting Perfusion and the Effects of Cannabidiol in Psychosis Risk.

ABSTRACT:

Background

Preclinical and human data suggest that psychosis onset involves hippocampal glutamatergic dysfunction, driving hyperactivity and hyperperfusion in a hippocampal-midbrain-striatal circuit. Whether glutamatergic dysfunction is related to cerebral perfusion in patients at clinical high risk (CHR) for psychosis, and whether cannabidiol (CBD) has ameliorative effects on glutamate or its relationship with perfusion remains unknown.

Methods

Using a double-blind, parallel-group design, 33 CHR patients were randomized to a single 600 mg dose of CBD or placebo; 19 healthy controls did not receive any drug. Proton magnetic resonance spectroscopy was used to measure glutamate concentrations in left hippocampus. We examined differences relating to CHR status (controls vs plac

SUBMITTER: Davies C 

PROVIDER: S-EPMC11207663 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature