Convergence of inputs from the basal ganglia with layer 5 of motor cortex and cerebellum in mouse motor thalamus.

ABSTRACT: A key to motor control is the motor thalamus, where several inputs converge. One excitatory input originates from layer 5 of primary motor cortex (M1_L5), while another arises from the deep cerebellar nuclei (Cb). M1_L5 terminals distribute throughout the motor thalamus and overlap with GABAergic inputs from the basal ganglia output nuclei, the internal segment of the globus pallidus (GPi), and substantia nigra pars reticulata (SNr). In contrast, it is thought that Cb and basal ganglia inputs are segregated. Therefore, we hypothesized that one potential function of the GABAergic inputs from basal ganglia is to selectively inhibit, or gate, excitatory signals from M1_L5 in the motor thalamus. Here, we tested this possibility and determined the circuit organizat

SUBMITTER: Koster KP 

PROVIDER: S-EPMC11208046 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature