SPACA6P-AS: a trailblazer in breast cancer pathobiology and therapeutics.

ABSTRACT:

Objective

The primary objective of this investigation is to delve into the involvement of the long noncoding RNA (lncRNA) SPACA6P-AS in breast cancer (BC) development, focusing on its expression pattern, association with clinical-pathological features, impact on prognosis, as well as its molecular and immunological implications.

Methods

Bioinformatics analysis was conducted utilizing RNA sequencing data of 1083 BC patients from the TCGA database. Functional exploration of SPACA6P-AS was carried out through the construction of survival curves, GO and KEGG enrichment analysis, and single-sample gene set enrichment analysis (ssGSEA). Furthermore, its functionality was validated through in vitro cell experiments and in vivo nude mouse model experiments.

Results

SPACA6P-AS

SUBMITTER: Feng W 

PROVIDER: S-EPMC11208203 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature