Dataset Information

Can blood-based markers predict RECIST progression in non-small cell lung cancer treated with immunotherapy?

ABSTRACT:

Purpose

In this study, we aimed to evaluate the potential of routine blood markers, serum tumour markers and their combination in predicting RECIST-defined progression in patients with stage IV non-small cell lung cancer (NSCLC) undergoing treatment with immune checkpoint inhibitors.

Methods

We employed time-varying statistical models and machine learning classifiers in a Monte Carlo cross-validation approach to investigate the association between RECIST-defined progression and blood markers, serum tumour markers and their combination, in a retrospective cohort of 164 patients with NSCLC.

Results

The performance of the routine blood markers in the prediction of progression free survival was moderate. Serum tumour markers and their combination with routine blood markers generally improved performance compared to routine blood markers alone. Elevated levels of C-reactive protein (CRP) and alkaline phosphatase (ALP) ranked as the top predictive routine blood markers, and CYFRA 21.1 was consistently among the most predictive serum tumour markers. Using these classifiers to predict overall survival yielded moderate to high performance, even when cases of death-defined progression were excluded. Performance varied across the treatment journey.

Conclusion

Routine blood tests, especially when combined with serum tumour markers, show moderate predictive value of RECIST-defined progression in NSCLC patients receiving immune checkpoint inhibitors. The relationship between overall survival and RECIST-defined progression may be influenced by confounding factors.

SUBMITTER: Yeghaian M

PROVIDER: S-EPMC11208229 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature

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Publications

Can blood-based markers predict RECIST progression in non-small cell lung cancer treated with immunotherapy?

Yeghaian Melda M Tareco Bucho Teresa M TM de Bruin Melissa M Schmitz Alexander A Bodalal Zuhir Z Smit Egbert F EF Beets-Tan Regina G H RGH van den Broek Daan D Trebeschi Stefano S

Journal of cancer research and clinical oncology 20240626 6

<h4>Purpose</h4>In this study, we aimed to evaluate the potential of routine blood markers, serum tumour markers and their combination in predicting RECIST-defined progression in patients with stage IV non-small cell lung cancer (NSCLC) undergoing treatment with immune checkpoint inhibitors.<h4>Methods</h4>We employed time-varying statistical models and machine learning classifiers in a Monte Carlo cross-validation approach to investigate the association between RECIST-defined progression and bl ...[more]

PMID: 38922374

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Dataset Information

Can blood-based markers predict RECIST progression in non-small cell lung cancer treated with immunotherapy?

Purpose

Methods

Results

Conclusion

Publications

Can blood-based markers predict RECIST progression in non-small cell lung cancer treated with immunotherapy?

Similar Datasets

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