Negative regulation of HDAC3 transcription by histone acetyltransferase TIP60 in colon cancer.

ABSTRACT:

Background

Colon cancer is the third most common cancer globally. The expression of histone deacetylase 3 (HDAC3) is upregulated, whereas the expression of tat interactive protein, 60 kDa (TIP60) is downregulated in colon cancer. However, the relationship between HDAC3 and TIP60 in colon cancer has not been clearly elucidated.

Objective

We investigated whether TIP60 could regulate the expression of HDAC3 and suppress colon cancer cell proliferation.

Methods

RNA sequencing data (GSE108834) showed that HDAC3 expression was regulated by TIP60. Subsequently, we generated TIP60-knockdown HCT116 cells and examined the expression of HDAC3 by western blotting and reverse transcription-quantitative polymerase chain reaction (RT-qPCR). We examined the expression pattern of HDAC

SUBMITTER: Lee SY 

PROVIDER: S-EPMC11208239 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature