Prognostic role of quantitative [18F]FDG PET/CT parameters in adrenocortical carcinoma.

ABSTRACT:

Purpose

We aimed to evaluate the prognostic potential of baseline [¹⁸F]FDG PET/CT for overall survival (OS) in patients with adrenocortical carcinoma (ACC).

Methods

We performed a retrospective analysis of 67 treatment-naïve ACC patients with available [¹⁸F]FDG PET/CT at time of initial diagnosis. Pretherapeutic PETs of primary tumors were manually segmented and quantitative parameters (maximum/mean/peak standardized uptake value (SUV_{max/mean/peak}), metabolic tumor volume (MTV) and tumor lesion glycolysis (TLG, defined as TV*SUV_mean) were derived. Based on a visual read, absence (M0) or presence of metastatic disease (M1) were evaluated. Kaplan-Meier and Cox regression analyses were used to determine the prognostic value of the abo

SUBMITTER: Schlotelburg W 

PROVIDER: S-EPMC11208261 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature