Assessing the predictive value of smoking history for immunotherapy outcomes in bladder cancer patients.

ABSTRACT:

Background

The therapeutic effectiveness of immune checkpoint inhibitors (ICIs) in bladder cancer varies among individuals. Identifying reliable predictors of response to these therapies is crucial for optimizing patient outcomes.

Methods

This retrospective study analyzed 348 bladder cancer patients treated with ICIs, with additional validation using data from 248 patients at our institution who underwent PD-L1 immunohistochemical staining. We examined patient smoking history, clinicopathological characteristics, and immune phenotypes. The main focus was the correlation between smoking history and immunotherapy outcomes. Multivariate logistic and Cox proportional hazard regressions were used to adjust for confounders.

Results

The study cohort comprised 348 bladder can

SUBMITTER: Kong J 

PROVIDER: S-EPMC11208302 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature