A prospective clinical study of the influence of oral protein intake on [¹⁸F]FET-PET uptake and test-retest repeatability in glioma.

ABSTRACT:

Background

O-(2-[¹⁸F]fluoroethyl)-L-tyrosine positron emission tomography ([¹⁸F]FET PET) scanning is used in routine clinical management and evaluation of gliomas with a recommended 4 h prior fasting. Knowledge of test-retest variation of [¹⁸F]FET PET imaging uptake metrics and the impact of accidental protein intake can be critical for interpretation. The aim of this study was to investigate the repeatability of [¹⁸F]FET-PET metrics and to assess the impact of protein-intake prior to [¹⁸F]FET PET scanning of gliomas.

Results

Test-retest variability in the non-protein group was good with absolute (and relative) upper and lower limits of agreement of + 0.15 and - 0.13 (+ 9.7% and - 9.0%) for mean tumour-to-background rati

SUBMITTER: Chehri S 

PROVIDER: S-EPMC11208353 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature