A feasibility study of in vivo quantitative ultra-short echo time-MRI for detecting early cartilage degeneration.

ABSTRACT:

Objectives

To explore the feasibility of Ultra-short echo time (UTE) - MRI quantitative imaging in detecting early cartilage degeneration in vivo and underlying pathological and biochemical basis.

Methods

Twenty volunteers with osteoarthritis (OA) planning for total knee arthroplasty (TKA) were prospectively recruited. UTE-MRI sequences and conventional sequences were performed preoperatively. Regions of interests (ROIs) were manually drawn on the tibial plateau and lateral femoral condyle images to calculate MRI values. Cartilage samples were collected during TKA according to the preset positions corresponding to MR images. Pathological and biochemical components of the corresponding ROI, including histological grading, glycosaminoglycan (GAG) content, collagen integrity, a

SUBMITTER: Su X 

PROVIDER: S-EPMC11208376 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature