Metabotropic signaling within somatostatin interneurons controls transient thalamocortical inputs during development.

ABSTRACT: During brain development, neural circuits undergo major activity-dependent restructuring. Circuit wiring mainly occurs through synaptic strengthening following the Hebbian "fire together, wire together" precept. However, select connections, essential for circuit development, are transient. They are effectively connected early in development, but strongly diminish during maturation. The mechanisms by which transient connectivity recedes are unknown. To investigate this process, we characterize transient thalamocortical inputs, which depress onto somatostatin inhibitory interneurons during development, by employing optogenetics, chemogenetics, transcriptomics and CRISPR-based strategies in mice. We demonstrate that in contrast to typical activity-dependent mechanisms, transient thalamocortic

SUBMITTER: Dwivedi D 

PROVIDER: S-EPMC11208423 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature