Transcriptomic convergence despite genomic divergence drive field cancerization in synchronous squamous tumors.

ABSTRACT:

Introduction

Field cancerization is suggested to arise from imbalanced differentiation in individual basal progenitor cells leading to clonal expansion of mutant cells that eventually replace the epithelium, although without evidence.

Methods

We performed deep sequencing analyses to characterize the genomic and transcriptomic landscapes of field change in two patients with synchronous aerodigestive tract tumors.

Results

Our data support the emergence of numerous genetic alterations in cancer-associated genes but refutes the hypothesis that founder mutation(s) underpin this phenomenon. Mutational signature analysis identified defective homologous recombination as a common underlying mutational process unique to synchronous tumors.

Discussion

Our analyses suggest

SUBMITTER: Tan QX 

PROVIDER: S-EPMC11208456 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature