Modulation of adipose-derived stem cell behavior by prostate pathology-associated plasma: insights from in vitro exposure.

ABSTRACT: Adipose-derived stem cells (ADSCs) are promising in regenerative medicine. Their proliferation, survival and activation are influenced by specific signals within their microenvironment, also known as niche. The stem cell niche is regulated by complex interactions between multiple cell types. When transplanted in a specific area, ADSCs can secrete several immunomodulatory factors. At the same time, a tumor microenvironment can influence stem cell behavior, modulating proliferation and their ability to differentiate into a specific phenotype. Whitin this context, we exposed ADSCs to plasma samples derived from human patients diagnosed with prostate cancer (PC), or precancerous lesions (PL), or benign prostatic hyperplasia (BPH) for 4, 7 or 10 days. We then analyzed the expression of main ste

SUBMITTER: Cruciani S 

PROVIDER: S-EPMC11208502 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature