NMR-based metabolomics identification of potential serum biomarkers of disease progression in patients with multiple sclerosis.

ABSTRACT: Multiple sclerosis (MS) is a chronic and progressive neurological disorder, characterized by neuroinflammation and demyelination within the central nervous system (CNS). The etiology and the pathogenesis of MS are still unknown. Till now, no satisfactory treatments, diagnostic and prognostic biomarkers are available for MS. Therefore, we aimed to investigate metabolic alterations in patients with MS compared to controls and across MS subtypes. Metabolic profiles of serum samples from patients with MS (n = 90) and healthy control (n = 30) were determined by Nuclear Magnetic Resonance (¹H-NMR) Spectroscopy using cryogenic probe. This approach was also utilized to identify significant differences between the metabolite profiles of the MS groups (primary progressive, secondary progr

SUBMITTER: Alwahsh M 

PROVIDER: S-EPMC11208524 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature