Genome-wide association study identifies host genetic variants influencing oral microbiota diversity and metabolic health.

ABSTRACT: The microbial communities of the oral cavity are important elements of oral and systemic health. With emerging evidence highlighting the heritability of oral bacterial microbiota, this study aimed to identify host genome variants that influence oral microbial traits. Using data from 16S rRNA gene amplicon sequencing, we performed genome-wide association studies with univariate and multivariate traits of the salivary microbiota from 610 unrelated adults from the Danish ADDITION-PRO cohort. We identified six single nucleotide polymorphisms (SNPs) in human genomes that showed associations with abundance of bacterial taxa at different taxonomical tiers (P < 5 × 10^-8). Notably, SNP rs17793860 surpassed our study-wide significance threshold (P < 1.19 × 10^-9). Additionally,

SUBMITTER: Stankevic E 

PROVIDER: S-EPMC11208528 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature