In vitro effect of visfatin on endocrine functions of the porcine corpus luteum.

ABSTRACT: Previously, we demonstrated the expression of visfatin in porcine reproductive tissues and its effect on pituitary endocrinology. The objective of this study was to examine the visfatin effect on the secretion of steroid (P₄, E₂) and prostaglandin (PGE₂, PGF_2α), the mRNA and protein abundance of steroidogenic markers (STAR, CYP11A1, HSD3B, CYP19A1), prostaglandin receptors (PTGER2, PTGFR), insulin receptor (INSR), and activity of kinases (MAPK/ERK1/2, AKT, AMPK) in the porcine corpus luteum. We noted that the visfatin effect strongly depends on the phase of the estrous cycle: on days 2-3 and 14-16 it reduced P₄, while on days 10-12 it stimulated P₄. Visfatin increased secretion of E₂ on days 2-3, PGE₂ o

SUBMITTER: Mlyczynska E 

PROVIDER: S-EPMC11208563 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature