Calcineurin/NFATc1 pathway represses cellular cytotoxicity by modulating histone H3 expression.

ABSTRACT: Excess amounts of histones in the cell induce mitotic chromosome loss and genomic instability, and are therefore detrimental to cell survival. In yeast, excess histones are degraded by the proteasome mediated via the DNA damage response factor Rad53. Histone expression, therefore, is tightly regulated at the protein level. Our understanding of the transcriptional regulation of histone genes is far from complete. In this study, we found that calcineurin inhibitor treatment increased histone protein levels, and that the transcription factor NFATc1 (nuclear factor of activated T cells 1) repressed histone transcription and acts downstream of the calcineurin. We further revealed that NFATc1 binds to the promoter regions of many histone genes and that histone transcription is downregulated in a

SUBMITTER: Sato Y 

PROVIDER: S-EPMC11208570 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature