Airway epithelial-derived exosomes induce acute asthma exacerbation after respiratory syncytial virus infection.

ABSTRACT: Acute asthma exacerbation refers to the progressive deterioration of asthma symptoms that is always triggered by virus infection represented by respiratory syncytial virus (RSV). After RSV infection, exaggerated Th2-mediated pulmonary inflammation is the critical pathological response of asthmatic patients with acute exacerbation. Significantly, airway epithelial cells, being the primary targets of RSV infection, play a crucial role in controlling the pulmonary inflammatory response by releasing airway epithelial cell-derived exosomes (AEC-Exos), which potentially influence the development of asthma. However, the specific role of AEC-Exos in acute asthma exacerbation after RSV infection remains obscure. The purpose of this study was to determine the distinct function of AEC-Exos in exacerb

SUBMITTER: Yao Y 

PROVIDER: S-EPMC11208743 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature