Real-World Survival Comparisons Between Radiotherapy and Surgery for Metachronous Second Primary Lung Cancer and Predictions of Lung Cancer-Specific Outcomes Using Machine Learning: Population-Based Study.

ABSTRACT:

Background

Metachronous second primary lung cancer (MSPLC) is not that rare but is seldom studied.

Objective

We aim to compare real-world survival outcomes between different surgery strategies and radiotherapy for MSPLC.

Methods

This retrospective study analyzed data collected from patients with MSPLC between 1988 and 2012 in the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching (PSM) analyses and machine learning were performed to compare variables between patients with MSPLC. Survival curves were plotted using the Kaplan-Meier method and were compared using log-rank tests.

Results

A total of 2451 MSPLC patients were categorized into the following treatment groups: 864 (35.3%) received radiotherapy, 759 (31%) underwent surg

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC11208834 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature