Rare and Common Genetic Variation Underlying Atrial Fibrillation Risk.

ABSTRACT:

Importance

Atrial fibrillation (AF) has a substantial genetic component. The importance of polygenic risk is well established, while the contribution of rare variants to disease risk warrants characterization in large cohorts.

Objective

To identify rare predicted loss-of-function (pLOF) variants associated with AF and elucidate their role in risk of AF, cardiomyopathy (CM), and heart failure (HF) in combination with a polygenic risk score (PRS).

Design, setting, and participants

This was a genetic association and nested case-control study. The impact of rare pLOF variants was evaluated on the risk of incident AF. HF and CM were assessed in cause-specific Cox regressions. End of follow-up was July 1, 2022. Data were analyzed from January to October 2023. The UK Biobank

SUBMITTER: Vad OB 

PROVIDER: S-EPMC11209175 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature