Population-Based Risk of Psychiatric Disorders Associated With Recurrent Copy Number Variants.

ABSTRACT:

Importance

Recurrent copy number variants (rCNVs) have been associated with increased risk of psychiatric disorders in case-control studies, but their population-level impact is unknown.

Objective

To provide unbiased population-based estimates of prevalence and risk associated with psychiatric disorders for rCNVs and to compare risks across outcomes, rCNV dosage type (deletions or duplications), and locus features.

Design, setting, and participants

This genetic association study is an analysis of data from the Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH) case-cohort sample of individuals born in Denmark in 1981-2008 and followed up until 2015, including (1) all individuals (n = 92 531) with a hospital discharge diagnosis of attention-de

SUBMITTER: Vaez M 

PROVIDER: S-EPMC11209205 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature