Immuno-Microbial Signature of Vaccine-Induced Immunity against SARS-CoV-2.

ABSTRACT: Although vaccines address critical public health needs, inter-individual differences in responses are not always considered in their development. Understanding the underlying basis for these differences is needed to optimize vaccine effectiveness and ultimately improve disease control. In this pilot study, pre- and post-antiviral immunological and gut microbiota features were characterized to examine inter-individual differences in SARS-CoV-2 mRNA vaccine response. Blood and stool samples were collected before administration of the vaccine and at 2-to-4-week intervals after the first dose. A cohort of 14 adults was separated post hoc into two groups based on neutralizing antibody levels (high [HN] or low [LN]) at 10 weeks following vaccination. Bivariate correlation analysis was per

SUBMITTER: Umeda L 

PROVIDER: S-EPMC11209251 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature