Modularized supramolecular assemblies for hypoxia-activatable fluorescent visualization and image-guided theranostics.

ABSTRACT: Rationale: Molecular imaging of microenvironment by hypoxia-activatable fluorescence probes has emerged as an attractive approach to tumor diagnosis and image-guided treatment. Difficulties remain in its translational applications due to hypoxia heterogeneity in tumor microenvironments, making it challenging to image hypoxia as a reliable proxy of tumor distribution. Methods: We report a modularized theranostics platform to fluorescently visualize hypoxia via light-modulated signal compensation to overcome tumor heterogeneity, thereby serving as a diagnostic tool for image-guided surgical resection and photodynamic therapy. Specifically, the platform integrating dual modules of fluorescence indicator and photodynamic moderator using supramolecular host-guest self-assembly, wh

SUBMITTER: Liu W 

PROVIDER: S-EPMC11209709 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature