One-Year Effects of High-Intensity Statin on Bioactive Lipids: Findings From the JUPITER Trial.

ABSTRACT:

Background

Statin effects extend beyond low-density lipoprotein cholesterol reduction, potentially modulating the metabolism of bioactive lipids (BALs), crucial for biological signaling and inflammation. These bioactive metabolites may serve as metabolic footprints, helping uncover underlying processes linked to pleiotropic effects of statins and yielding a better understanding of their cardioprotective properties. This study aimed to investigate the impact of high-intensity statin therapy versus placebo on plasma BALs in the JUPITER trial (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin; NCT00239681), a randomized primary prevention trial involving individuals with low-density lipoprotein cholesterol <130 mg/dL and high-sensitivity

SUBMITTER: Hoshi RA 

PROVIDER: S-EPMC11209760 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature