Elevated senescence-associated secretory phenotype index in late-life bipolar disorder.

ABSTRACT:

Background

The senescence-associated secretory phenotype (SASP) is a biomarker index based on the profile of 22 blood proteins associated with cellular senescence. The SASP index has not been assessed in older patients with bipolar disorder (BD). We hypothesized that older adults with BD will have elevated cellular senescence burden as measured by the SASP index.

Methods

We measured the 22 SASP proteins to calculate the SASP index in 38 older patients with BD and 34 non-psychiatric comparison individuals (HC).

Results

The SASP index scores were significantly higher in BD than HC after controlling for age, sex, psychopathology, and physical health (F(1,8) = 5.37, p = 0.024, η2 = 0.08). SASP index scores were also associated with higher age, more severe depressive sympt

SUBMITTER: Tessema T 

PROVIDER: S-EPMC11209851 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature