Insights into Metabolites Profiling and Pharmacological Investigation of <i>Aconitum heterophyllum</i> wall ex. Royle Stem through Experimental and Bioinformatics Techniques.

ABSTRACT: The Aconitum genus is a leading source of a wide range of structurally diverse metabolites with significant pharmacological implications. The present study investigated metabolite profiling, pharmacological investigation, anticancer potential, and molecular docking analysis of the stem part of Aconitum heterophyllum (AHS). The metabolite profiling of the AHS extract was experimentally examined using LC-MS/MS-orbitrap in both modes (ESI⁺/ESI^-) and GC-MS in EI mode. The in vitro MTT model was used to study the anticancer potential, while the in vivo animal model was used to study the anti-inflammatory and antinociceptive activities. The MOE software was used for the molecular docking study. A total of 118 novel and previously known metabolite

SUBMITTER: Ilyas M 

PROVIDER: S-EPMC11209905 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature