Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics.

ABSTRACT:

Background

Aging is a prominent risk factor for diverse diseases; therefore, an in-depth understanding of its physiological mechanisms is required. Nonhuman primates, which share the closest genetic relationship with humans, serve as an ideal model for exploring the complex aging process. However, the potential of the nonhuman primate animal model in the screening of human aging markers is still not fully exploited. Multiomics analysis of nonhuman primate peripheral blood offers a promising approach to evaluate new therapies and biomarkers. This study explores aging-related biomarker through multilayer omics, including transcriptomics (mRNA, lncRNA, and circRNA) and proteomics (serum and serum-derived exosomes) in rhesus monkeys (Macaca mulatta).

Results

Our findings reveal

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11209966 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature