LMO family gene polymorphisms and Wilms tumor susceptibility in Chinese children: a five-center case-control study.

ABSTRACT:

Background

Wilms tumor is the most prevalent embryonal kidney malignancy in children worldwide. Previous genome-wide association study (GWAS) identified that LIM domain only 1 (LMO1) gene polymorphisms affected the susceptibility to develop certain tumor types. Apart from LMO1, the LMO gene family members also include LMO2-4, each of which has oncogenic potential.

Methods

We conducted this five-center case‒control study to assess the correlations between single nucleotide polymorphisms in LMO family genes and Wilms tumor susceptibility. Odds ratios and 95% confidence intervals were calculated to evaluate the strength of the association.

Results

We found LMO1 rs2168101 G > T and rs11603024 C > T as well as LMO2 rs7933499 G > A were significantly associated with Wilms t

SUBMITTER: Fu W 

PROVIDER: S-EPMC11209997 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature