Causal relationship between prostatic diseases and prostate cancer: a mendelian randomization study.

ABSTRACT:

Background

Although it is thought that prostatitis or benign prostatic hyperplasia (BPH) is related to prostate cancer (PCa), the underlying causal effects of these diseases are unclear.

Methods

We assessed the causal relationship between prostatitis or BPH and PCa using a two-sample Mendelian randomization (MR) approach. The data utilized in this study were sourced from genome-wide association study. The association of genetic variants from cohorts of prostatitis or BPH and PCa patients was determined using inverse-variance weighted and MR Egger regression techniques. The direction of chance was determined using independent genetic variants with genome-wide significance (P < 5 × 10^-6). The accuracy of the results was confirmed using sensitivity analyses.

Resul

SUBMITTER: Huang J 

PROVIDER: S-EPMC11210166 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature