Immune evasion impacts the landscape of driver genes during cancer evolution.

ABSTRACT:

Background

Carcinogenesis is driven by interactions between genetic mutations and the local tumor microenvironment. Recent research has identified hundreds of cancer driver genes; however, these studies often include a mixture of different molecular subtypes and ecological niches and ignore the impact of the immune system.

Results

In this study, we compare the landscape of driver genes in tumors that escaped the immune system (escape +) versus those that did not (escape -). We analyze 9896 primary tumors from The Cancer Genome Atlas using the ratio of non-synonymous to synonymous mutations (dN/dS) and find 85 driver genes, including 27 and 16 novel genes, in escape - and escape + tumors, respectively. The dN/dS of driver genes in immune escaped tumors is significantly lower

SUBMITTER: Gourmet L 

PROVIDER: S-EPMC11210199 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature