Mechanistic insights into super-enhancer-related genes as prognostic signatures in colon cancer.

ABSTRACT:

Background

Colon cancer (CC) is the most frequently occurring digestive system malignancy and is associated with a dismal prognosis. While super-enhancer (SE) genes have been identified as prognostic markers in several cancers, their potential as practical prognostic markers for CC patients remains unexplored.

Methods

We obtained super-enhancer-related genes (SERGs) from the Human Super-Enhancer Database (SEdb). Transcriptome and relevant clinical data for colon cancer (CC) were sourced from the Gene Expression Omnibus (GEO) database. Subsequently, we identified up-regulated SERGs by the Weighted Gene Co-expression Network Analysis (WGCNA). Prognostic signatures were constructed via univariate and multivariate Cox regression analysis. We then delved into the mechanisms of th

SUBMITTER: Tang Y 

PROVIDER: S-EPMC11210223 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature