Dietary sucrose determines the regulatory activity of lithium on gene expression and lifespan in Drosophila melanogaster.

ABSTRACT: The amount of dietary sugars and the administration of lithium both impact the lifespan of the fruit fly Drosophila melanogaster. It is noteworthy that lithium is attributed with insulin-like activity as it stimulates protein kinase B/Akt and suppresses the activity of glycogen synthase kinase-3 (GSK-3). However, its interaction with dietary sugar has largely remained unexplored. Therefore, we investigated the effects of lithium supplementation on known lithium-sensitive parameters in fruit flies, such as lifespan, body composition, GSK-3 phosphorylation, and the transcriptome, while varying the dietary sugar concentration. For all these parameters, we observed that the efficacy of lithium was significantly influenced by the sucrose content in the diet. Overall, we found that lithiu

SUBMITTER: Jans K 

PROVIDER: S-EPMC11210232 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature