Prognostic implication and immunotherapy response prediction of a novel ubiquitination-related gene signature in liver cancer.

ABSTRACT: HCC, also known as hepatocellular carcinoma, is a frequently occurring form of cancer with an unfavorable prognosis. This research constructed a prognostic signature related to ubiquitination and investigated its correlation with the response to immunotherapy in HCC. The Molecular Signatures Database provided a compilation of genes associated with ubiquitination. A gene signature related to ubiquitination was obtained through Cox regression using the Least Absolute Shrinkage and Selection Operator method. The genetic factors CPY26B1, MCM10, SPINK4, and TRIM54 notably impacted the outcomes of HCC. The patients were divided into two groups: one group had a high risk of poor survival while the other had a low risk but a greater chance of controlling HCC progression. Both univariate and multiv

SUBMITTER: Pan RG 

PROVIDER: S-EPMC11210240 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature