Interaction of hydrocortisone and illness severity on head growth in cohort of ELBW infants.

ABSTRACT:

Background

Extremely low birth weight (ELBW) infants comprise a fragile population at risk for neurodevelopmental disabilities (NDD). Systemic steroids were previously associated with NDD, but more recent studies suggest hydrocortisone (HCT) may improve survival without increasing NDD. However, the effects of HCT on head growth adjusted for illness severity during NICU hospitalization are unknown. Thus, we hypothesize that HCT will protect head growth, accounting for illness severity using a modified neonatal Sequential Organ Failure Assessment (M-nSOFA) score.

Methods

We conducted a retrospective study that included infants born at 23-29 weeks gestational age (GA) and < 1000 g. Our study included 73 infants, 41% of whom received HCT.

Results

We found negative correla

SUBMITTER: Chen H 

PROVIDER: S-EPMC11210266 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature