Genetic ancestry is related to potential sources of breast cancer health disparities among Colombian women.

ABSTRACT: Breast cancer health disparities are linked to clinical-pathological determinants, socioeconomic inequities, and biological factors such as genetic ancestry. These factors collectively interact in complex ways, influencing disease behavior, especially among highly admixed populations like Colombians. In this study, we assessed contributing factors to breast cancer health disparities according to genetic ancestry in Colombian patients from a national cancer reference center. We collected non-tumoral paraffin embedded (FFPE) blocks from 361 women diagnosed with breast cancer at the National Cancer Institute (NCI) to estimate genetic ancestry using a 106-ancestry informative marker (AIM) panel. Differences in European, Indigenous American (IA) and African ancestry fractions were analyzed acco

SUBMITTER: Rey-Vargas L 

PROVIDER: S-EPMC11210782 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature