A high-throughput behavioral screening platform for measuring chemotaxis by C. elegans.

ABSTRACT: Throughout history, humans have relied on plants as a source of medication, flavoring, and food. Plants synthesize large chemical libraries and release many of these compounds into the rhizosphere and atmosphere where they affect animal and microbe behavior. To survive, nematodes must have evolved the sensory capacity to distinguish plant-made small molecules (SMs) that are harmful and must be avoided from those that are beneficial and should be sought. This ability to classify chemical cues as a function of their value is fundamental to olfaction and represents a capacity shared by many animals, including humans. Here, we present an efficient platform based on multiwell plates, liquid handling instrumentation, inexpensive optical scanners, and bespoke software that can efficiently determi

SUBMITTER: Fryer E 

PROVIDER: S-EPMC11210793 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature