PTPRD gene variant rs10739150: A potential game-changer in hypertension diagnosis.

ABSTRACT:

Background

High blood pressure, also known as hypertension (HTN), is a complicated disorder that is controlled by a complex network of physiological processes. Untreated hypertension is associated with increased death incidence, rise the need for understanding the genetic basis affecting hypertension susceptibility and development. The current study sought to identify the genetic association between twelve single nucleotide polymorphisms (SNPs) within seven candidate genes (NOS3, NOS1AP, REN, PLA2G4A, TCF7L, ADRB1, and PTPRD).

Methods

The current study included 200 Jordanian individuals diagnosed with hypertension, compared to 224 healthy controls. Whole blood samples were drawn from each individual for DNA isolation and genotyping. The SNPStats tool was used to assess haplo

SUBMITTER: Al-Eitan L 

PROVIDER: S-EPMC11210811 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature