TGF-β ligand cross-subfamily interactions in the response of Caenorhabditis elegans to a bacterial pathogen.

ABSTRACT: The Transforming Growth Factor beta (TGF-β) family consists of numerous secreted peptide growth factors that play significant roles in cell function, tissue patterning, and organismal homeostasis, including wound repair and immunity. Typically studied as homodimers, these ligands have the potential to diversify their functions through ligand interactions that may enhance, repress, or generate novel functions. In the nematode Caenorhabditis elegans, there are only five TGF-β ligands, providing an opportunity to dissect ligand interactions in fewer combinations than in vertebrates. As in vertebrates, these ligands can be divided into bone morphogenetic protein (BMP) and TGF-β/Activin subfamilies that predominantly signal through discrete signaling pathways. The BMP subfamily ligand DBL-1 has

SUBMITTER: Ciccarelli EJ 

PROVIDER: S-EPMC11210861 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature